Can a car use 100-octane petrol?

The short answer
In most cases, yes. A gasoline (petrol) car designed for unleaded fuel can generally run on 100-octane unleaded without harm. Octane rating measures a fuel's resistance to knock, meaning uncontrolled early combustion in the cylinder. It is not a measure of how much energy the fuel contains. Using a higher rating than your engine needs does not damage it, but it also does not automatically add power or improve fuel economy.
The answer changes in three situations: when the 100-octane fuel is leaded, when its ethanol content exceeds what your vehicle allows, and when the vehicle uses a diesel engine. Each is covered below.
What 100 octane means, and how it differs from regular and premium
Higher-octane fuel tolerates more heat and pressure before it ignites on its own. That matters most in engines with high compression ratios or forced induction, such as turbochargers and superchargers, because these create the conditions where knock is more likely. An engine designed for regular fuel does not create those conditions, so extra knock resistance has nothing to do.
The number on the pump also depends on how it was measured. US pumps display the Anti-Knock Index (AKI), which is the average of two laboratory methods, Research Octane Number (RON) and Motor Octane Number (MON). Many other markets display RON alone, and RON is typically several points higher than AKI for the same fuel. A fuel advertised as 100 octane outside the US is therefore not directly comparable to a fuel labelled 100 at a US pump. Check which scale a label uses before comparing fuels or reading advice written for another market.
Will your engine benefit?
Engines designed for regular fuel: no meaningful benefit is expected, because the engine is not calibrated to use the extra knock resistance. Engines where premium is recommended: many modern engines use knock sensors to adjust ignition timing to the fuel, so higher octane may let them run closer to their intended calibration. Any gain from going beyond the recommended grade depends on the specific engine, and no model-specific test data was available for this article. Engines where premium is required, or vehicles with aftermarket tuning: these may be calibrated for a particular octane level. Follow the manufacturer's or tuner's specification rather than assuming more is better.
Fuels to avoid even if they say 100 octane
Leaded racing fuel: some race fuels contain lead and are sold for off-road or competition use only. Lead can damage catalytic converters and oxygen sensors, and using leaded fuel in a road vehicle is not permitted in the US. Aviation gasoline: common piston-aircraft fuel is leaded and is not intended for cars, regardless of its octane rating. High-ethanol blends beyond your vehicle's limit: some high-octane fuels get part of their rating from ethanol. Check your owner's manual for the maximum ethanol blend your vehicle accepts. Any gasoline in a diesel vehicle: octane does not apply to diesel engines, and putting gasoline in a diesel tank can cause serious damage.
What to do next
Check the fuel requirement in your owner's manual or on the label inside the fuel door, and note whether it describes the grade as required or recommended. If you are considering 100-octane fuel, confirm that it is unleaded, approved for road use, and within your vehicle's ethanol limit. Treat claims of extra power or efficiency with caution unless they come from your vehicle's manufacturer or from documented testing on your specific engine.
Limits of this guidance
This article explains general fuel principles only. No model-specific specifications, test results, pricing or availability data were available for it. Fuel requirements vary by model year, engine, trim and market, so your vehicle's documentation and manufacturer guidance take precedence over general advice.

